> Proteins, Peptides & Amino Acids > Recombinant Protein > Cytokine > Recombinant Mouse IL-7 ProteinBrand |
Leading Biology | Catalog Number |
PM0016E2 |
Product Type |
Cytokine | Field of Research |
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Nature |
Recombinant Protein
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Expression Host |
E.coli
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Species |
Mouse
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AA Sequence |
NP_032397.1(Glu26-Ile154)
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Tags |
Tag-Free
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Molecular Weight |
18KD
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Activity |
Measured in a cell proliferation assay using PHA-activated human peripheral blood lymphocytes (PBL)
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Form |
Lyophilized |
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Purity |
Greater than 95% by SDS-PAGE |
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Storage & Stability |
-70°C
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Storage Buffer |
0.2 μm filtered PBS, pH7.4
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Product Description |
The target cells of IL-7 are mainly lymphocytes, and have growth-promoting activities against B progenitor cells derived from human or mouse bone marrow, thymocytes, and peripheral mature T cells. Synergistic with stem cell growth factor (SCF) can stimulate mitosis of b precursor, which can be inhibited by tgf and inhibited; but has no significant effect on the growth of progenitor B (pro-b). Promote the maturation of double-negative thymocytes, and provide the initial signal of tcr gene recombination during embryonic thymocyte development; however, it has no obvious effect on mature T cells. Inducing thymocytes or peripheral blood lymphocytes to produce LAK cell activity, the effector cells are mainly CD8+ subpopulations; however, IL-7-induced LAK cells do not have NK activity.IL-7 can stimulate myeloid precursor cells and megakaryocytes to produce colony forming units and platelets, which can restore the body from the immunosuppressive effect of cyclophosphamide; at higher concentrations, IL-7 can also enhance macrophages. Cytotoxic activity, induces monocyte secretion of cytokines.
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Synonyms |
Interleukin-7 Protein (Mouse)
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Images |
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Quantity |
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Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
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