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Recombinant Protein >
Recombinant Human PD-L1 Protein(C-His)Brand |
Leading Biology | Catalog Number |
PH0163M1 |
Product Type |
Recombinant Protein | Field of Research |
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Expression Host |
Mammalian cell
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Species |
Human
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AA Sequence |
NP_054862.1
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Tags |
C-His
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Molecular Weight |
25KDa
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Activity |
Measured by its binding ability in a functional ELISA . Immobilized human B7-H1 at 10 μg/ml (100 μl/well) can bind human PD1 with a linear ranger of 0.3-0.9 μg/ml .
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Function |
Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.
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Form |
Liquid |
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Purity |
Greater than 98% by SDS-PAGE |
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Storage & Stability |
Store at -20°C short term. For long-term storage, aliquot and store at -70°C or below. Stable for 12 months at -70°C. Avoid repeated freeze-thaw cycles.
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Storage Buffer |
0.2 μm filtered PBS, pH7.4
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Synonyms |
B7-H Protein(Human); PDCD1L1 Protein(Human)
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Images |
SDS-PAGE of our Recombinant Human PD-L1 Protein(C-His) |
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Quantity |
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Select | Brand | Catalog No. | Product Name | Pack Size | Type | Field of Research | Specification | Quantity | Price(USD) | |
1 | Leading Biology | PH0009E2 | Recombinant Human STING Protein | Recombinant Protein |
|
$695.00 | Add Ask | |||
2 | Leading Biology | PH0164E1 | SARS-CoV-2 Nucleoprotein | 10ug | Recombinant Protein |
|
$99.00 | Add Ask | ||
3 | Leading Biology | PH0167M1 | SARS-CoV-2 Spike (541) Protein | 20ug | Recombinant Protein |
|
$99.00 | Add Ask | ||
4 | Leading Biology | PH0167E1 | SARS-CoV-2 RBD Protein | 10ug | Recombinant Protein |
|
$99.00 | Add Ask | ||
5 | Leading Biology | PH0005E1 | Recombinant Human FGL1 Protein | 10ug | Recombinant Protein |
|
$195.00 | Add Ask | ||
6 | Leading Biology | PH0168M1 | SARS-CoV-2 RBD (L452R, E484Q) Protein (His Tag) | 100μg | Recombinant Protein |
|
$495.00 | Add Ask |
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