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Location: Home > Proteins, Peptides & Amino Acids > Recombinant Protein > Recombinant Human PD-L1 Protein(C-His)

Recombinant Human PD-L1 Protein(C-His)

PH0163M1
Catalog # Availability Size / Price Inquiry
PR027131S-1 100μg / $495
PR027131S-2 200μg / $955

Recombinant Human PD-L1 Protein(C-His)

Brand

Leading Biology

Catalog Number

PH0163M1

Product Type

Recombinant Protein

Field of Research

Expression Host

Mammalian cell

Species

Human

AA Sequence

NP_054862.1

Tags

C-His

Molecular Weight

25KDa

Activity

Measured by its binding ability in a functional ELISA . Immobilized human B7-H1 at 10 μg/ml (100 μl/well) can bind human PD1 with a linear ranger of 0.3-0.9 μg/ml .

Function

Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.

Form

Liquid

Purity

Greater than 98% by SDS-PAGE

Storage & Stability

Store at -20°C short term. For long-term storage, aliquot and store at -70°C or below. Stable for 12 months at -70°C. Avoid repeated freeze-thaw cycles.

Storage Buffer

0.2 μm filtered PBS, pH7.4

Synonyms

B7-H Protein(Human); PDCD1L1 Protein(Human)

Images

SDS-PAGE of our Recombinant Human PD-L1 Protein(C-His)

Quantity

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