> Proteins, Peptides & Amino Acids > Recombinant Protein > Recombinant Human FGL1 ProteinBrand |
Leading Biology | Catalog Number |
PH0005E1 |
Product Type |
Recombinant Protein | Field of Research |
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Nature |
Recombinant Protein
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Expression Host |
E.coli
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Species |
Human
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AA Sequence |
NP_004458.3 (Leu 23-Ile 312)
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Molecular Weight |
35 KD
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Activity |
Measured by its ability to bind biotinylated LAG3 domain1/2 in functional ELISA.
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Form |
Liquid |
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Concentration |
0.6mg/mL |
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Purity |
Greater than 95% by SDS-PAGE |
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Storage & Stability |
-70ºC
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Storage Buffer |
0.2 μm filtered PBS, pH7.4
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Product Description |
Fibrinogen-like protein 1 (FGL1), a liver-secreted protein, is a major LAG-3 functional ligand independent from MHC-II. FGL1 inhibits antigen-specific T cell activation, and ablation of FGL1 in mice promotes T cell immunity. Blockade of the FGL1-LAG-3 interaction by monoclonal antibodies stimulates tumor immunity and is therapeutic against established mouse tumors in a receptor-ligand inter-dependent manner.
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Synonyms |
Fibrinogen-like protein 1 (human), HFREP1 Protein, Human; HP-041 Protein, Human; LFIRE-1 Protein, Human; LFIRE1 Protein, Human
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Images |
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Quantity |
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Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
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