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Recombinant Protein >
Recombinant Human STING ProteinBrand |
Leading Biology | Catalog Number |
PH0009E2 |
Product Type |
Recombinant Protein | Field of Research |
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Nature |
Recombinant Protein
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Expression Host |
E.coli
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Species |
Human
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AA Sequence |
NP_938023.1 (Lys 137-Ser 379)
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Molecular Weight |
27.4 KD
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Activity |
The result from the ITC assay showed that cGAMP bound Recombinant Human STING Protein with a dissociation constant of 0.02 μM.
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Form |
Liquid |
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Concentration |
10μg-0.3mg/mL
50μg-0.75mg/mL
200μg-1mg/mL |
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Purity |
Greater than 95% by SDS-PAGE |
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Storage & Stability |
-70ºC
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Storage Buffer |
0.2 μm filtered 50mM Tris-HCl, 150mM NaCl, pH7.5
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Product Description |
Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Essential for the induction of IFN-beta in response to human herpes simplex virus 1 (HHV-1) infection. Exhibits 2',3' phosphodiester linkage-specific ligand recognition. Can bind both 2'-3' linked cGAMP and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP.(Microbial infection) Antiviral activity is antagonized by oncoproteins, such as papillomavirus (HPV) protein E7 and adenovirus early E1A protein (PubMed: 26405230). Such oncoproteins prevent the ability to sense cytosolic DNA.
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Synonyms |
ERIS protein, Human; MITA protein ,Human; Transmembrane protein 173
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Images |
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Quantity |
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Select | Brand | Catalog No. | Product Name | Pack Size | Type | Field of Research | Specification | Quantity | Price(USD) | |
1 | Leading Biology | PH0164E1 | SARS-CoV-2 Nucleoprotein | 10ug | Recombinant Protein |
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$99.00 | Add Ask | ||
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3 | Leading Biology | PH0167E1 | SARS-CoV-2 RBD Protein | 10ug | Recombinant Protein |
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4 | Leading Biology | PH0005E1 | Recombinant Human FGL1 Protein | 10ug | Recombinant Protein |
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$195.00 | Add Ask | ||
5 | Leading Biology | PH0168M1 | SARS-CoV-2 RBD (L452R, E484Q) Protein (His Tag) | 100μg | Recombinant Protein |
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$495.00 | Add Ask | ||
6 | Leading Biology | PC0001M1 | ORF1ab polyprotein (pp1ab) | 100ul | Recombinant Protein | pneumonia virus |
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$495.00 | Add Ask |
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