> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > Peroxiredoxin-6 AntibodyBrand |
Leading Biology | Catalog Number |
APR09051G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Peroxiredoxin-6 antibody.
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Molecular Weight |
25035 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm. Lysosome. Cytoplasmic vesicle. Note=Also found in lung secretory organelles.
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Host |
Rabbit
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Species Reactivity |
Human, Mouse, Rat
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Target |
A synthetic peptide corresponding to residues of human Peroxiredoxin 6 was used as an immunogen.
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Clone |
EPR3754
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Symbol |
AOP2, KIAA0106
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GeneID |
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UniProt ID |
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Function |
Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.
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Summary |
Peroxiredoxins (Prx) are a family of ubiquitous antioxidant enzymes which regulates cytokine-induced peroxide levels and mediates signal transduction in various mammalian cells. Prx family members have been linked to cell proliferation, differentiation, and apoptosis (1). Peroxiredoxin 6 (Prdx6) is only mammalian 1-Cys member of the peroxiredoxin family and it is expressed in all major organs, with particularly high expression in lung. Prdx6 is considered antioxidant enzyme and has a major role in lung phospholipid metabolism. Specifically, Prdx6 might be involved in antioxidant defense by facilitating repair of damaged cell membranes via reduction of peroxidized phospholipids and alterations of lung surfactant phospholipid synthesis and turnover (2).
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Form |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC
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Dilution |
WB~~1:1000~5000
IHC~~1:250~500
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Synonyms |
Peroxiredoxin-6, 1-Cys peroxiredoxin, 1-Cys PRX, 24 kDa protein, Acidic calcium-independent phospholipase A2, aiPLA2, 311-, Antioxidant protein 2, Liver 2D page spot 40, Non-selenium glutathione peroxidase, NSGPx, Red blood cells page spot 12, PRDX6, AOP2, KIAA0106
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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