> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - With BSA and AzideBrand |
Leading Biology | Catalog Number |
AMM00172G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - With BSA and Azide.
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Molecular Weight |
49kDa
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Cellular Localization |
Antigen Cellular Localization:
Cell membrane; Single-pass type I membrane protein. Endosome membrane. Note=Subject to intracellular trafficking between the cell membrane and endosomes. Localizes to cell surface lipid rafts
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Host |
Mouse
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Species Reactivity |
Human
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Target |
Human thymus cells
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Clone |
O10
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Isotype |
IgG1, kappa
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GeneID |
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UniProt ID |
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Function |
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
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Summary |
At least five CD1 genes (CD1a, b, c, d, and e) are identified. CD1 proteins have been demonstrated to restrict T cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation. CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta-2 microglobulin. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a is reported to be a new marker for perivascular epithelial cell tumor (PEComa).
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Form |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC, IF, FC, IP, E
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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