> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > PDZK1 AntibodyBrand |
Leading Biology | Catalog Number |
APR09028G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PDZK1 antibody.
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Molecular Weight |
57129 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein. Cell membrane. Note=Associated with peripheral membranes Localizes to the apical compartment of proximal tubular cells and to sinusoidal liver membranes (By similarity).
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Host |
Rabbit
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Species Reactivity |
Human
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Target |
A synthetic peptide corresponding to residues in human PDZK1 was used as an immunogen.
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Clone |
EPR3751
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Symbol |
CAP70, NHERF3, PDZD1
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GeneID |
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UniProt ID |
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Function |
A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity).
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Summary |
PDZ domain-containing protein 1 (PDZK1) is a scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells (1). PDZK1 is suggested to play multiple roles in normal physiology and may influence associated disorders. It is involved in maintaining hepatic SR-BI levels and controlling HDL metabolism, protects against the development of atherosclerosis and also mediates SR-BI-dependent regulation of endothelial cell biology by HDL (2). PDZK1 expression is limited to epithelial cells, located in the kidney, pancreas, liver, and small intestine. It is also expressed at a lower level in the adrenal cortex, testis and stomach, and it is over-expressed in breast, renal and lung carcinomas (1).
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Form |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC, IF
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Dilution |
WB~~1:5000~20000
IHC~~1:100~250
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Synonyms |
Na(+)/H(+) exchange regulatory cofactor NHE-RF3, NHERF-3, CFTR-associated protein of 70 kDa, Na(+)/H(+) exchanger regulatory factor 3, Na/Pi cotransporter C-terminal-associated protein 1, NaPi-Cap1, PDZ domain-containing protein 1, Sodium-hydrogen exchanger regulatory factor 3, PDZK1, CAP70, NHERF3, PDZD1
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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