> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > PDK2 AntibodyBrand |
Leading Biology | Catalog Number |
APR09000G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PDK2 antibody.
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Molecular Weight |
46154 Da
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Cellular Localization |
Antigen Cellular Localization:
Mitochondrion matrix.
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Host |
Rabbit
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Species Reactivity |
Human, Mouse, Rat
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Target |
A synthetic peptide corresponding to residues near the C-terminus of human PDK2 was used as an immunogen.
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Clone |
EPR1948Y
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Symbol |
PDHK2
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GeneID |
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UniProt ID |
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Function |
Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis.
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Summary |
A member of Pyruvate dehydrogenase kinase (PDK1, 2, 3, and 4), PDK2 is a serine kinase which is involved in the regulation of mammalian glucose metabolism. During aerobic energy metabolism, mitochondrial pyruvate dehydrogenase complex (PDC) catalyzes decarboxylation of pyruvate to form acetyl-CoA (1). PDK2 inhibits PDC thru phosphorylation of the E1 alpha subunit of PDC and inactivates the complex (2). Highly expressed in heart and skeletal muscles, PDK2 is also responsible for the phosphorylation of Akt at Ser473, which leads to phosphorylation by PDK1 on Thr308 on Akt and full Akt activation (3).
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Form |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC
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Dilution |
WB~~10000~100000
IHC~~1:100~250
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Synonyms |
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial, Pyruvate dehydrogenase kinase isoform 2, PDH kinase 2, PDKII, PDK2, PDHK2
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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