> Proteins, Peptides & Amino Acids > Recombinant Protein > Cytokine > Recombinant Human TNFSF11 ProteinBrand |
Leading Biology | Catalog Number |
PH0149E2 |
Product Type |
Cytokine | Field of Research |
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Nature |
Recombinant Protein
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Expression Host |
E.coli
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Species |
Human
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AA Sequence |
O14788-2(Gly 63-Asp 244)
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Tags |
Tag-Free
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Molecular Weight |
27KD
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Form |
lyophilized |
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Purity |
Greater than 95% by SDS-PAGE |
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Storage & Stability |
-70°C
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Storage Buffer |
0.2 μm filtered PBS, pH7.4
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Product Description |
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy . Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation
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Synonyms |
CD254 Protein(Human); ODF Protein(Human); OPGL Protein(Human); OPTB2 Protein(Human); RANKL Protein(Human); sOdf Protein(Human); TRANCE Protein(Human)
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Images |
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Quantity |
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| Select | Brand | Catalog No. | Product Name | Pack Size | Type | Field of Research | Specification | Quantity | Price(USD) | |
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$195.00 | Add Ask | ||
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$325.00 | Add Ask | ||
| 4 | Leading Biology | PH0041M1 | Recombinant Human IL-34 Protein (C-His Tag) | 20μg | Cytokine |
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$325.00 | Add Ask | ||
| 5 | Leading Biology | PH0024E3 | Recombinant Human IL-16 Protein (N-His Tag) | 20μg | Cytokine |
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$325.00 | Add Ask | ||
| 6 | Leading Biology | PM0036M1 | Recombinant Mouse IL-28A Protein (C-His Tag) | 20μg | Cytokine |
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$325.00 | Add Ask |
Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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