> Proteins, Peptides & Amino Acids > Recombinant Protein > Cytokine > Recombinant Human LTA ProteinBrand |
Leading Biology | Catalog Number |
PH0131E2 |
Product Type |
Cytokine | Field of Research |
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Nature |
Recombinant Protein
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Expression Host |
E.coli
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Species |
Human
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AA Sequence |
P01374(Leu 35-Leu 205)
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Tags |
Tag-Free
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Molecular Weight |
19KD
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Form |
lyophilized |
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Purity |
Greater than 95% by SDS-PAGE |
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Storage & Stability |
-70°C
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Storage Buffer |
0.2 μm filtered PBS, pH7.4
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Product Description |
Lymphotoxin alpha, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. LT-α1-β2 can interact with receptors such as LT-β receptors. Absence of LT-β on cell surfaces will diminish the ability of LT-α to form LT-α1-β2, thus decreasing its effective ability as a cytokine. LT-α mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. LT-α is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. In LT-α knockout mice, Peyer's patches and lymph nodes will fail to develop, thus illustrating the cytokine's essential role in immunological development. As a cytotoxic protein, LT-α causes the destruction of cancerous cell lines, activates signaling pathways, and effectively kills transformed tumor cells. However, mice with overexpression of LT-α or LT-β showed increased tumor growth and metastasis in several models of cancer. In other studies, mice with gene knockout of LT-α showed enhanced tumor growth, implicating possible protective role of LT-α in cancer. However, these studies utilized mice with complete LT-α deficiency that did not allow to distinguish effects of soluble versus membrane-associated LT.
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Synonyms |
LT Protein(Human); TNFB Protein(Human); TNFSF1 Protein(Human); TNF beta Protein(Human)
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Images |
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Quantity |
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Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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