> Proteins, Peptides & Amino Acids > Recombinant Protein > Cytokine > Recombinant Human FGF1 ProteinBrand |
Leading Biology | Catalog Number |
PH0104E2 |
Product Type |
Cytokine | Field of Research |
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Nature |
Recombinant Protein
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Expression Host |
E.coli
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Species |
Human
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AA Sequence |
AAA79245.1(Phe 16-Asp 155)
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Tags |
Tag-Free
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Molecular Weight |
16KD
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Activity |
Measured in a cell proliferation assay using NR6R-3T3 mouse fibroblast cells.
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Form |
lyophilized |
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Purity |
Greater than 95% by SDS-PAGE |
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Storage & Stability |
-70°C
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Storage Buffer |
0.2 μm filtered PBS, pH7.4
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Product Description |
FGF1, also known as acidic fibroblast growth factor (aFGF), is a growth factor and signaling protein encoded by the FGF1 gene. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Three alternatively spliced variants encoding different isoforms have been described. FGF1 is multifunctional with many reported effects. For one example, in mice with diet-induced diabetes that is an experimental equivalent of type 2 diabetes in humans, a single injection of the FGF1 protein is enough to restore blood sugar levels to a healthy range for > 2 days.
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Synonyms |
AFGF Protein(Human); ECGF Protein(Human); ECGF-beta Protein(Human); ECGFA Protein(Human); ECGFB Protein(Human); FGF-alpha Protein(Human); FGFA Protein(Human); GLIO703 Protein(Human); HBGF-1 Protein(Human); HBGF1 Protein(Human)
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Images |
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Quantity |
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