> Proteins, Peptides & Amino Acids > Recombinant Protein > Cytokine > Recombinant Human LAG3 Protein(C-His Tag)Brand |
Leading Biology | Catalog Number |
PH0099M1 |
Product Type |
Cytokine | Field of Research |
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Nature |
Recombinant Protein
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Expression Host |
Mammalian cell
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Species |
Human
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AA Sequence |
NP_002277.4(Met1-Leu450)
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Tags |
C-His
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Molecular Weight |
47KD
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Activity |
Measured by its ability to induce TNF-alpha secretion by JAWSII mouse immature dendritic cells.
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Form |
lyophilized |
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Purity |
Greater than 95% by SDS-PAGE |
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Storage & Stability |
-70°C
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Storage Buffer |
0.2 μm filtered PBS, pH7.4
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Product Description |
Lymphocyte-activation gene 3, also known as LAG-3, is a protein which in humans is encoded by the LAG3 gene. LAG3, which was discovered in 1990 and was designated CD223 (cluster of differentiation 223) after the Seventh Human Leucocyte Differentiation Antigen Workshop in 2000, is a cell surface molecule with diverse biologic effects on T cell function. It is an immune checkpoint receptor and as such is the target of various drug development programs by pharmaceutical companies seeking to develop new treatments for cancer and autoimmune disorders. In soluble form it is also being developed as a cancer drug in its own right. LAG3's main ligand is MHC class II, to which it binds with higher affinity than CD4. The protein negatively regulates cellular proliferation, activation, and homeostasis of T cells, in a similar fashion to CTLA-4 and PD-1 and has been reported to play a role in Treg suppressive function. Fibrinogen-like protein1 FGL1, a liver-secreted protein, is another (major) LAG3 functional ligand independent of MHC-II. LAG3 also helps maintain CD8+ T cells in a tolerogenic state[9] and, working with PD-1, helps maintain CD8 exhaustion during chronic viral infection. LAG3 is known to be involved in the maturation and activation of dendritic cells.
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Synonyms |
CD223 Protein(Human)
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Images |
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Quantity |
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| Select | Brand | Catalog No. | Product Name | Pack Size | Type | Field of Research | Specification | Quantity | Price(USD) | |
| 1 | Leading Biology | PH0003E1 | Recombinant Human TNF Alpha Protein | 10ug | Cytokine |
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$195.00 | Add Ask | ||
| 2 | Leading Biology | PH0001E2 | Recombinant Human IL-6 Protein | 10ug | Cytokine |
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$195.00 | Add Ask | ||
| 3 | Leading Biology | PH0073E2 | Recombinant Human CXCL2 Protein | 20μg | Cytokine |
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$325.00 | Add Ask | ||
| 4 | Leading Biology | PH0041M1 | Recombinant Human IL-34 Protein (C-His Tag) | 20μg | Cytokine |
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$325.00 | Add Ask | ||
| 5 | Leading Biology | PH0024E3 | Recombinant Human IL-16 Protein (N-His Tag) | 20μg | Cytokine |
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$325.00 | Add Ask | ||
| 6 | Leading Biology | PM0036M1 | Recombinant Mouse IL-28A Protein (C-His Tag) | 20μg | Cytokine |
|
$325.00 | Add Ask |
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Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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