> Proteins, Peptides & Amino Acids > Recombinant Protein > Cytokine > Recombinant Human ErbB2 Protein(C-His Tag)Brand |
Leading Biology | Catalog Number |
PH0096M1 |
Product Type |
Cytokine | Field of Research |
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Nature |
Recombinant Protein
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Expression Host |
Mammalian cell
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Species |
Human
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AA Sequence |
NP_004439.2(Met 1-Thr 652)
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Tags |
C-His
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Molecular Weight |
100KD
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Activity |
Measured by its ability to block anti-ErbB2 mediated inhibition of SK-BR-3 human breast cancer cell proliferation.
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Form |
lyophilized |
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Purity |
Greater than 95% by SDS-PAGE |
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Storage & Stability |
-70°C
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Storage Buffer |
0.2 μm filtered PBS, pH7.4
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Product Description |
Receptor tyrosine-protein kinase erbB-2, also known as CD340 (cluster of differentiation 340), proto-oncogene Neu, Erbb2 (rodent), or ERBB2 (human), is a protein that in humans is encoded by the ERBB2 gene. ERBB is abbreviated from erythroblastic oncogene B, a gene isolated from avian genome. It is also frequently called HER2 (from human epidermal growth factor receptor 2) or HER2/neu. HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients. The ErbB family consists of four plasma membrane-bound receptor tyrosine kinases. One of which is erbB-2, and the other members being epidermal growth factor receptor, erbB-3 (neuregulin-binding; lacks kinase domain), and erbB-4. All four contain an extracellular ligand binding domain, a transmembrane domain, and an intracellular domain that can interact with a multitude of signaling molecules and exhibit both ligand-dependent and ligand-independent activity. Notably, no ligands for HER2 have yet been identified. HER2 can heterodimerise with any of the other three receptors and is considered to be the preferred dimerisation partner of the other ErbB receptors.
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Synonyms |
CD340 Protein(Human); ENV Protein(Human); ENVW Protein(Human); ERVWE1 Protein(Human); HER-2 Protein(Human); HER2 Protein(Human); HERV-7q Protein(Human); HERV-W-ENV Protein(Human); HERV7Q Protein(Human); HERVW Protein(Human); HERVWENV Protein(Human); MLN 19 Protein(Human); MLN19 Protein(Human); NEU Protein(Human); NGL Protein(Human); TKR1 Protein(Human)
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Images |
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Quantity |
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| Select | Brand | Catalog No. | Product Name | Pack Size | Type | Field of Research | Specification | Quantity | Price(USD) | |
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