> Proteins, Peptides & Amino Acids > Recombinant Protein > Cytokine > Recombinant Human TIGIT Protein(C-His Tag)Brand |
Leading Biology | Catalog Number |
PH0092M1 |
Product Type |
Cytokine | Field of Research |
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Nature |
Recombinant Protein
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Expression Host |
Mammalian cell
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Species |
Human
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AA Sequence |
NP_776160.2(Met 1-Phe 138)
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Tags |
C-His
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Molecular Weight |
14KD
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Activity |
Measured by its ability to bind with human CD155 in a functional ELISA.
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Form |
lyophilized |
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Purity |
Greater than 95% by SDS-PAGE |
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Storage & Stability |
-70°C
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Storage Buffer |
0.2 μm filtered PBS, pH7.4
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Product Description |
TIGIT (also called T cell immunoreceptor with Ig and ITIM domains) is an immune receptor present on some T cells and Natural Killer Cells(NK). It is also identified as WUCAM and Vstm3. TIGIT could bind to CD155(PVR) on dendritic cells(DCs), macrophages, etc. with high affinity, and also to CD112(PVRL2) with lower affinity. Research has shown that TIGIT-Fc fusion protein could interact with PVR on dendritic cells and increase its IL-10 secretion level/decrease its IL-12 secretion level under LPS stimulation, and also inhibit T cell activation in vivo. TIGIT's inhibition of NK cytotoxicity can be blocked by antibodies against its interaction with PVR and the activity is directed through its ITIM domain.
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Synonyms |
VSIG9 Protein(Human); VSTM3 Protein(Human); WUCAM Protein(Human)
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Images |
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Quantity |
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| Select | Brand | Catalog No. | Product Name | Pack Size | Type | Field of Research | Specification | Quantity | Price(USD) | |
| 1 | Leading Biology | PH0003E1 | Recombinant Human TNF Alpha Protein | 10ug | Cytokine |
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$195.00 | Add Ask | ||
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$325.00 | Add Ask | ||
| 4 | Leading Biology | PH0041M1 | Recombinant Human IL-34 Protein (C-His Tag) | 20μg | Cytokine |
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$325.00 | Add Ask | ||
| 5 | Leading Biology | PH0024E3 | Recombinant Human IL-16 Protein (N-His Tag) | 20μg | Cytokine |
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$325.00 | Add Ask | ||
| 6 | Leading Biology | PM0036M1 | Recombinant Mouse IL-28A Protein (C-His Tag) | 20μg | Cytokine |
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$325.00 | Add Ask |
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Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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