> Proteins, Peptides & Amino Acids > Recombinant Protein > Cytokine > Recombinant Human CXCL5 ProteinBrand |
Leading Biology | Catalog Number |
PH0076E2 |
Product Type |
Cytokine | Field of Research |
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Nature |
Recombinant Protein
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Expression Host |
E.coli
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Species |
Human
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AA Sequence |
P42830(Arg45-Asn114)
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Tags |
Tag-Free
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Molecular Weight |
8KD
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Activity |
Measured by its ability to induce myeloperoxidase release from cytochalasin B-treated human neutrophils.
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Form |
lyophilized |
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Purity |
Greater than 95% by SDS-PAGE |
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Storage & Stability |
-70°C
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Storage Buffer |
0.2 μm filtered 80% acetonitrile, 0.1% TFA, 20% H2O
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Product Description |
CXCL5 is a small cytokine belonging to the CXC chemokine family that is also known as epithelial-derived neutrophil-activating peptide 78 (ENA-78). It is produced following stimulation of cells with the inflammatory cytokines interleukin-1 or tumor necrosis factor-alpha. Expression of CXCL5 has also been observed in eosinophils, and can be inhibited with the type II interferon IFN-γ. This chemokine stimulates the chemotaxis of neutrophils possessing angiogenic properties. It elicits these effects by interacting with the cell surface chemokine receptor CXCR2. The gene for CXCL5 is encoded on four exons and is located on human chromosome 4 amongst several other CXC chemokine genes. CXCL5 has been implicated in connective tissue remodelling. CXCL5 has been also described to regulate neutrophil homeostasis.
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Synonyms |
ENA-78 Protein(Human); SCYB5 Protein(Human)
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Images |
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Quantity |
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