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Phospho-Pyk2-Y402 pAb

Catalog # Availability Size / Price Inquiry
AMR01026N-1 50ul / $395
AMR01026N-2 100ul / $495
AMR01026N-3 200ul / $595

Phospho-Pyk2-Y402 pAb

Brand

Leading Biology

Catalog Number

AMR01026N

Product Type

Phosphorylated Antibodies

Field of Research

Cell Biology & Developmental Biology>Apoptosis

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Phospho-Pyk2-Y402 pAb.

Molecular Weight

Calculated MW: 111kDa/115kDa Observed MW: 116kDa

Species Reactivity

Rabbit

Immunogen

A synthetic phosphorylated peptide around Y402 of human Pyk2 (NP_004094.3).

Cross Reactivity

Human

Isotype

IgG

GeneID

UniProt ID

Purity

Affinity purification

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Storage Buffer

Buffer: PBS with 50% glycerol, pH7.3.

Applications

WB

Dilution

WB 1:500 - 1:2000

Product Description

This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.

Synonyms

PTK2B; CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2; RAFTK; protein-tyrosine kinase 2-beta

Images

Western blot analysis of extracts of Jurkat cells, using Phospho-Pyk2-Y402 antibody.

Specification

Quantity

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