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Phospho-CDK6-Y13 pAb

Catalog # Availability Size / Price Inquiry
AMR00899N-1 50ul / $395
AMR00899N-2 100ul / $495
AMR00899N-3 200ul / $595

Phospho-CDK6-Y13 pAb

Brand

Leading Biology

Catalog Number

AMR00899N

Product Type

Phosphorylated Antibodies

Field of Research

Cell Biology & Developmental Biology>Cell Cycle

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Phospho-CDK6-Y13 pAb.

Molecular Weight

Calculated MW: 36kDa Observed MW: 37kDa

Species Reactivity

Rabbit

Immunogen

A phospho specific peptide corresponding to residues surrounding Y13 of human CDK6

Cross Reactivity

Human,Mouse

Isotype

IgG

GeneID

UniProt ID

Purity

Affinity purification

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Storage Buffer

Buffer: PBS with 50% glycerol, pH7.3.

Applications

WB,IHC,IF

Dilution

WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:100 - 1:200

Product Description

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Synonyms

CDK6; MCPH12; PLSTIRE; cyclin-dependent kinase 6

Images

Western blot analysis of extracts from 293 cells using Phospho-CDK6-Y13 antibody.

Specification

Quantity

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