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Phospho-CCND1-T286 pAb

Catalog # Availability Size / Price Inquiry
AMR01002N-1 50ul / $395
AMR01002N-2 100ul / $495
AMR01002N-3 200ul / $595

Phospho-CCND1-T286 pAb

Brand

Leading Biology

Catalog Number

AMR01002N

Product Type

Phosphorylated Antibodies

Field of Research

Cell Biology & Developmental Biology>Cell Cycle

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Phospho-CCND1-T286 pAb.

Molecular Weight

Calculated MW: 33kDa Observed MW: 36kDa

Species Reactivity

Rabbit

Immunogen

A synthetic phosphorylated peptide around T286 of human CCND1 (NP_444284.1).

Cross Reactivity

Human

Isotype

IgG

GeneID

UniProt ID

Purity

Affinity purification

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Storage Buffer

Buffer: PBS with 50% glycerol, pH7.3.

Applications

WB

Dilution

WB 1:500 - 1:2000

Product Description

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

Synonyms

CCND1; BCL1; D11S287E; PRAD1; U21B31; cyclin D1

Images

Western blot analysis of extracts of 293T cells, using Phospho-CCND1-T286 antibody.

Specification

Quantity

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