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Phosphorylated Antibodies >
Phospho-ATM-S1981 pAbBrand |
Leading Biology | Catalog Number |
AMR00767N |
Product Type |
Phosphorylated Antibodies | Field of Research |
Cell Biology & Developmental Biology>Apoptosis |
Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Phospho-ATM-S1981 pAb.
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Molecular Weight |
Calculated MW:
350kDa
Observed MW:
350kDa
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Species Reactivity |
Rabbit
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Immunogen |
A synthetic phosphorylated peptide around S1981 of human ATM (NP_000042.3).
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Cross Reactivity |
Human
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Isotype |
IgG
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GeneID |
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UniProt ID |
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Purity |
Affinity purification |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Storage Buffer |
Buffer: PBS with 50% glycerol, pH7.3.
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Applications |
WB,IF
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Dilution |
WB 1:500 - 1:2000
IF 1:50 - 1:200
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Product Description |
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.
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Synonyms |
ATM; AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1; serine-protein kinase ATM
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Images |
Western blot analysis of extracts of 293T cells, using Phospho-ATM-S1981 antibody. Immunofluorescence analysis of MCF-7 cells using Phospho-ATM-S1981 antibody. Immunofluorescence analysis of U2OS cells using Phospho-ATM-S1981 antibody. |
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Specification |
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Quantity |
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