> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Phosphorylated Antibodies > Phospho-NEDD4L-S448 pAbBrand |
Leading Biology | Catalog Number |
AMR01125N |
Product Type |
Phosphorylated Antibodies | Field of Research |
Protein phosphorylation |
Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Phospho-NEDD4L-S448 pAb.
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Molecular Weight |
Calculated MW:
96-111kDa
Observed MW:
130kDa
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Species Reactivity |
Rabbit
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Immunogen |
A synthetic phosphorylated peptide around S448 of human NEDD4L (NP_001138439.1).
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Cross Reactivity |
Human,Mouse,Rat
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Isotype |
IgG
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GeneID |
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UniProt ID |
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Purity |
Affinity purification |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Storage Buffer |
Buffer: PBS with 50% glycerol, pH7.3.
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Applications |
WB
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Dilution |
WB 1:500 - 1:2000
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Product Description |
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
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Synonyms |
NEDD4L; NEDD4-2; NEDD4.2; PVNH7; RSP5; hNEDD4-2; E3 ubiquitin-protein ligase NEDD4-like
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Images |
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Specification |
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Quantity |
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2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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