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Doublecortin (DCX) Antibody

Catalog # Availability Size / Price Inquiry
AMM05839G  In Stock 100 μl / $545

Doublecortin (DCX) Antibody

Brand

Leading Biology

Catalog Number

AMM05839G

Product Type

Monoclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Doublecortin (DCX) antibody.

Molecular Weight

35, 45 KDa

Host

Mouse

Species Reactivity

Bovine, Human, Mouse, Rat

Target

Full length recombinant human protein expressed in and purified from E. coli.

Clone

3 e1

Isotype

IgG2A

GeneID

UniProt ID

Summary

Doublecortin, or DCX, is a microtubule associated protein that is expressed almost exclusively in very early neuronal development (Brown et al., 2003), making it an excellent marker for developing neuronal cells. Defects in the DCX gene lead toX-linked lissencephaly which is characterized by a lack of normal folds on the surface of the brain resulting in a smooth cerebral cortex caused by abnormal migration of neurons during development (des Portes et al., 1998; Gleeson et al., 1998).

Form

Affinity purified from tissue culture supernatant.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

IF, WB

Dilution

WB~~ 1:5000 IF~~ 1:1000

Synonyms

Neuronal migration protein doublecortin, Doublin, Lissencephalin-X, Lis-X, DCX, DBCN, LISX

Images

Western blot of postnatal day 3 rat brain lysate showing specific immunolabeling of the ~35 & 45k doublecortin protein.

Immunofluorescence of cultured rat neurons showing strong cytoplasmicstaining of doublecortin (green) in developing neurons and GFAP in red.

Specification

Quantity

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