> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > KCNJ4 / Kir2.3 Antibody (aa390-445, clone S25-35)Brand |
Leading Biology | Catalog Number |
AMM06128G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality KCNJ4 / Kir2.3 antibody (aa390-445, clone S25-35).
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Molecular Weight |
50kDa
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Cellular Localization |
Antigen Cellular Localization:
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane. Note=TAX1BP3 binding promotes dissociation of KCNJ4 from LIN7 famaly members and KCNJ4 internalization
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Host |
Mouse
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Species Reactivity |
Human, Mouse, Rat
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Target |
Detects ~45 kD protein. No cross reactivity against Kir2.1, or Kir2.2.
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Clone |
S25-35
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Symbol |
IRK3
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GeneID |
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UniProt ID |
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Function |
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity).
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Summary |
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity).
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Form |
Liquid |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC-P, IF, ICC, IP
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Dilution |
ICC (0.1-1 μg/ml), IHC-P (5 μg/ml), IP (1-10 μg/ml), WB (1-10 μg/ml) ,
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Synonyms |
Inward rectifier potassium channel 4, HIRK2, HRK1, Hippocampal inward rectifier, HIR, Inward rectifier K(+) channel Kir2.3, IRK-3, Potassium channel, inwardly rectifying subfamily J member 4, KCNJ4, IRK3
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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