> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > KCNJ12 / Kir2.2 Antibody (aa362-427, clone S124B-38)Brand |
Leading Biology | Catalog Number |
AMM06101G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality KCNJ12 / Kir2.2 antibody (aa362-427, clone S124B-38).
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Molecular Weight |
49kDa
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Cellular Localization |
Antigen Cellular Localization:
Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
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Host |
Mouse
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Species Reactivity |
Human, Mouse, Rat
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Target |
Detects ~45 kD protein. No cross reactivity against Kir2.1, or Kir2.3.
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Clone |
S124B-38
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Symbol |
IRK2, KCNJN1
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GeneID |
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UniProt ID |
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Function |
Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
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Summary |
Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
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Form |
Liquid |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC-P, IF, ICC
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Dilution |
ICC (0.1-1 μg/ml), IHC-P (5 μg/ml), WB (1-10 μg/ml)
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Synonyms |
ATP-sensitive inward rectifier potassium channel 12, Inward rectifier K(+) channel Kir2.2, IRK-2, Inward rectifier K(+) channel Kir2.2v, Potassium channel, inwardly rectifying subfamily J member 12, KCNJ12, IRK2, KCNJN1
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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