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Location: Home > Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > CREBBP Antibody (monoclonal) (M01)

CREBBP Antibody (monoclonal) (M01)

Catalog # Availability Size / Price Inquiry
APG02781G 100 μg / $495

CREBBP Antibody (monoclonal) (M01)

Brand

Leading Biology

Catalog Number

APG02781G

Product Type

Monoclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CREBBP antibody (monoclonal) (M01).

Molecular Weight

265351 Da

Host

mouse

Species Reactivity

Human

Target

CREBBP (NP_004371, 951 a.a. ~ 1050 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone

2H5

Isotype

IgG1 kappa

GeneID

UniProt ID

Summary

This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms.

Form

Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IF, E

Dilution

WB~~1:500~1000

Synonyms

CREB-binding protein, CREBBP, CBP

Images

Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) .

Immunofluorescence of monoclonal antibody to CREBBP on HeLa cell . [antibody concentration 10 ug/ml]

Detection limit for recombinant GST tagged CREBBP is approximately 0.03ng/ml as a capture antibody.

Specification

Quantity

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