> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > IL1B Antibody (Center) (Ascites)Brand |
Leading Biology | Catalog Number |
APR07983G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality IL1B antibody (Center) (Ascites).
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Molecular Weight |
30748 Da
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Cellular Localization |
Antigen Cellular Localization:
Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins
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Host |
Mouse
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Species Reactivity |
Human
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Immunogen |
148-174 aa
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Target |
This IL1B antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 148-174 amino acids from the Central region of human IL1B.
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Clone |
614CT4.3.1
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Isotype |
IgG1
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Symbol |
IL1F2
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GeneID |
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UniProt ID |
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Function |
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
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Summary |
The protein encoded by this gene is a member of theinterleukin 1 cytokine family. This cytokine is produced byactivated macrophages as a proprotein, which is proteolyticallyprocessed to its active form by caspase 1 (CASP1/ICE). Thiscytokine is an important mediator of the inflammatory response, andis involved in a variety of cellular activities, including cellproliferation, differentiation, and apoptosis. The induction ofcyclooxygenase-2 (PTGS2/COX2) by this cytokine in the centralnervous system (CNS) is found to contribute to inflammatory painhypersensitivity. This gene and eight other interleukin 1 familygenes form a cytokine gene cluster on chromosome 2. [provided byRefSeq].
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Form |
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:2000~4000
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Synonyms |
Interleukin-1 beta, IL-1 beta, Catabolin, IL1B, IL1F2
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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