> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > MAP3K11 Antibody (ascites)Brand |
Leading Biology | Catalog Number |
APR17282G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality MAP3K11 antibody (ascites).
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Molecular Weight |
92688 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Location is cell cycle dependent
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Host |
Mouse
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Species Reactivity |
Human
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Target |
This MAP3K11 monoclonal antibody is generated from mouse immunized with MAP3K11 recombinant protein.
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Clone |
230CT5.3.1
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Isotype |
IgM,k
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GeneID |
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UniProt ID |
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Function |
Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.
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Summary |
The protein encoded by this gene is a member of theserine/threonine kinase family. This kinase contains a SH3 domainand a leucine zipper-basic motif. This kinase preferentiallyactivates MAPK8/JNK kinase, and functions as a positive regulatorof JNK signaling pathway. This kinase can directly phosphorylate,and activates IkappaB kinase alpha and beta, and is found to beinvolved in the transcription activity of NF-kappaB mediated by Rhofamily GTPases and CDC42.
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Form |
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:100~500
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Synonyms |
Mitogen-activated protein kinase kinase kinase 11, Mixed lineage kinase 3, Src-homology 3 domain-containing proline-rich kinase, MAP3K11 (HGNC:6850)
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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