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MAP4K3 Antibody

Catalog # Availability Size / Price Inquiry
APR08341G 100 μl / $495

MAP4K3 Antibody

Brand

Leading Biology

Catalog Number

APR08341G

Product Type

Monoclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MAP4K3 antibody.

Molecular Weight

101316 Da

Host

Mouse

Species Reactivity

Human

Target

This MAP4K3 monoclonal antibody is generated from mouse immunized with MAP4K3 recombinant protein.

Clone

219CT8.3.1

Isotype

IgM,k

Symbol

RAB8IPL1

GeneID

UniProt ID

Function

May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

Summary

This gene encodes a member of the Ste20 family ofserine/threonine protein kinases. The protein belongs to thesubfamily that consists of members, such as germinal center kinase(GCK), that are characterized by an N-terminal catalytic domain andC-terminal regulatory domain. The kinase activity of the encodedprotein can be stimulated by UV radiation and tumor necrosisfactor-alpha. The protein specifically activates the c-JunN-terminal kinase (JNK) signaling pathway. Evidence suggests thatit functions upstream of mitogen-activated protein kinase kinasekinase 1 (MEKK1). This gene previously was referred to asRAB8-interacting protein-like 1 (RAB8IPL1), but it has been renamedmitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3).

Form

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, E

Dilution

WB~~1:100~500 IHC-P~~1:100

Synonyms

Mitogen-activated protein kinase kinase kinase kinase 3, Germinal center kinase-related protein kinase, GLK, MAPK/ERK kinase kinase kinase 3, MEK kinase kinase 3, MEKKK 3, MAP4K3, RAB8IPL1

Images

Western blot analysis of lysate from MCF-7 cell line, using MAP4K3( APR08341G). APR08341G was diluted at 1:1000. A goat anti-mouse IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20μg.

Immunohistochemical analysis of paraffin-embedded H. skeletal muscle section using MAP4K3 Antibody( APR08341G). APR08341G was diluted at 1:100 dilution. A undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining.

Western blot analysis of lysates from HepG2, MCF-7 cell line (from left to right), using MAP4K3 Antibody( APR08341G). APR08341G was diluted at 1:1000 at each lane. A goat anti-mouse IgG H&L(HRP) at 1:3000 dilution was used as the secondary antibody. Lysates at 35μg per lane.

Specification

Quantity

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