> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > UBC-9 AntibodyBrand |
Leading Biology | Catalog Number |
APR10630G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality UBC-9 antibody.
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Molecular Weight |
18007 Da
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Cellular Localization |
Antigen Cellular Localization:
Nucleus. Cytoplasm. Note=Mainly nuclear. In spermatocytes, localizes in synaptonemal complexes. Recruited by BCL11A into the nuclear body (By similarity).
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Host |
Rabbit
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Species Reactivity |
Human, Mouse, Rat
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Target |
A synthetic peptide corresponding to residues near the N-terminus of human UBC9 was used as an immunogen.
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Clone |
EP2938Y
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Symbol |
UBC9, UBCE9
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GeneID |
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UniProt ID |
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Function |
Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly- SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'.
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Summary |
UBCs are a family of proteins directly involved in ubiquitination of proteins and in the control of cellular processes through the targeting of key regulatory proteins for degradation UBC9 is a homologue of the class E2 ubiquitin-conjugating enzymes (UBCs) (1). UBC9 possesses a distinct electrostatic potential distribution that may provide possible clues to its ability to interact with other proteins. It was suggested that different UBCs may utilize catalytic mechanisms of varying efficiency and substrate specificity (2). UBC9 has been shown to catalyze conjugation of a small ubiquitin-like molecule-1 (SUMO-1) to a variety of target proteins. SUMO-1 modifications were implicated in the targeting of proteins to the nuclear envelope and certain intranuclear structures and in converting proteins resistant to ubiquitin-mediated degradation. UBC9 also interacts with the androgen receptor (AR), a member of the steroid receptor family of ligand-activated transcription factors. It has the ability to act as an AR co-regulator in a fashion independent of its ability to catalyze SUMO-1 conjugation. (3).
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Form |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC
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Dilution |
WB~~1:1000~5000
IHC~~1:100~250
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Synonyms |
SUMO-conjugating enzyme UBC9, 632-, SUMO-protein ligase, Ubiquitin carrier protein 9, Ubiquitin carrier protein I, Ubiquitin-conjugating enzyme E2 I, Ubiquitin-protein ligase I, p18, UBE2I, UBC9, UBCE9
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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