> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > PKA, RII Antibody Phospho (pS99)Brand |
Leading Biology | Catalog Number |
AMR09298G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PKA, RII antibody Phospho (pS99).
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Molecular Weight |
45518 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm. Cell membrane. Note=Colocalizes with PJA2 in the cytoplasm and the cell membrane
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Host |
Rabbit
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Species Reactivity |
Human, Mouse, Rat
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Target |
A synthetic phospho-peptide corresponding to residues surrounding Ser99 of human PKA RII was used as immunogen. The antibody only detects PKA RII phosphorylated on Serine 99.
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Clone |
E151
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Symbol |
PKR2, PRKAR2
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GeneID |
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UniProt ID |
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Function |
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
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Summary |
PKA (or cAPK) is a cyclic AMP-dependent protein kinase. When activated by the second messenger cAMP, PKA mediates diverse cellular mechanisms, including proliferation, ion transport, regulation of metabolism, and gene transcription (1,2). PKA is comprised of two dimers of two subunits, R (regulatory) and C (catalytic). Two families of R subunits (RI and RII) have been identified, each possessing distinct cAMP binding properties and resulting in different phosphorylation states (2,3).
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Form |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
IHC, WB, IF
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Dilution |
IHC~~1:250
WB~~1:20000
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Synonyms |
cAMP-dependent protein kinase type II-alpha regulatory subunit, PRKAR2A, PKR2, PRKAR2
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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