> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > P2Y6 AntibodyBrand |
Leading Biology | Catalog Number |
APR17722G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality P2Y6 antibody.
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Molecular Weight |
36429 Da
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Cellular Localization |
Antigen Cellular Localization:
Cell membrane; Multi-pass membrane protein.
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Host |
Rabbit
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Species Reactivity |
Human
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Target |
A synthetic peptide corresponding to residues in human P2Y6 was used as an immunogen.
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Clone |
EPR3816
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GeneID |
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UniProt ID |
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Function |
Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
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Summary |
P2Y6 is a multi-pass membrane protein and P2Y receptor, belonging to the family of G-protein coupled receptor 1 (1). The P2Y family is composed of eight cloned and functionally defined subtypes, including five that are present in human tissues (P2Y1, P2Y2, P2Y4, P2Y6 and P2Y11) (2). P2Y6 is expressed in human spleen, placenta, thymus, intestine, and blood leukocytes and is a receptor for extracellular UDP, UTP and ADP (1). It contributes to microglia activation and their later phagocytosis in CNS, and in the immune system, it participates in the secretion of interleukin (IL)-8 from monocytes and macrocytes. It has been suggested that P2Y6 may play a role in neuroinflammation in CNS (3).
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Form |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC
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Dilution |
WB~~1:20000~50000
IHC~~1:100~250
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Synonyms |
P2Y purinoceptor 6, P2Y6, P2RY6
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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