> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > 14-3-3E AntibodyBrand |
Leading Biology | Catalog Number |
APR11361G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality 14-3-3E antibody.
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Molecular Weight |
29174 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm. Melanosome Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
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Host |
Rabbit
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Species Reactivity |
Human, Mouse, Rat
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Target |
A synthetic peptide corresponding to residues in human 14-3-3E was used as an immunogen.
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Clone |
EPR3918
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GeneID |
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UniProt ID |
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Function |
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
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Summary |
The 14-3-3 epsilon protein (14-3-3E) is one of seven isoforms in the 14-3-3 protein family; a family which consists of acidic 30 kDa proteins expressed at high levels in neurons of the central nervous system (1). It is an adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. 14-3-3E binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (2). It also interacts with both, the insulin-like growth factor I receptor (IGFIR) and the insulin receptor substrate I (IRS-1), suggesting its role in the regulation of insulin sensitivity (3). 14-3-3E has also been implicated in the pathogenesis of small cell lung cancer (4).
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Form |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IF
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Dilution |
WB~~1:20000~100000
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Synonyms |
14-3-3 protein epsilon, 14-3-3E, YWHAE
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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