> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > Functional IL-1R2 (mouse) Antibody, mAb (recombinant)Brand |
Leading Biology | Catalog Number |
AMP00009G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Functional IL-1R2 (mouse) Antibody, mAb (recombinant).
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Molecular Weight |
45645 Da
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Cellular Localization |
Antigen Cellular Localization:
Membrane; Single-pass type I membrane protein. Cell membrane. Secreted
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Host |
Purified From?HEK 293 Cell?culture Supernatant.
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Species Reactivity |
Mouse
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Target |
Recognizes mouse IL-1R2.
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Clone |
Praxy-1-1
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Isotype |
Mouse IgG2bλ
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Symbol |
Il-1r2, Il1rb
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GeneID |
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UniProt ID |
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Function |
Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (By similarity).
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Summary |
The inflammatory actions of IL-1α and -β- depend on their interaction with its receptor, IL-1R1, and can be negatively controlled by several inhibitors such as IL-1Ra, IL-1R type 2 (IL-1R2), SIGIRR and the soluble form of IL-1 receptor accessory protein (IL-1RAcP). IL-1R2 neutralizes IL-1 either as a surface decoy receptor or in a cleaved and secreted form. IL-1R2 is expressed on B cells, on neutrophils and on in vitro expanded human Tregs.
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Form |
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
FC, E
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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