> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > MVP Antibody (N-term) (Ascites)Brand |
Leading Biology | Catalog Number |
AMM02437G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality MVP Antibody (N-term) (Ascites).
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Molecular Weight |
99327 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm. Nucleus, nuclear pore complex. Note=5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment
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Host |
Mouse
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Species Reactivity |
Human
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Immunogen |
12-39 aa
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Target |
This MVP antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 12-39 amino acids from the N-terminal region of human MVP.
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Clone |
599CT2.4.1
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Isotype |
IgG1
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Symbol |
LRP
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GeneID |
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UniProt ID |
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Function |
Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
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Summary |
This gene encodes the major vault protein which is a lungresistance-related protein. Vaults are multi-subunit structuresthat may be involved in nucleo-cytoplasmic transport. This proteinmediates drug resistance, perhaps via a transport process. It iswidely distributed in normal tissues, and overexpressed inmultidrug-resistant cancer cells. The protein overexpression is apotentially useful marker of clinical drug resistance. This geneproduces two transcripts by using two alternative exon 2 sequences;however, the open reading frames are the same in both transcripts.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:100~1600
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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