> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > CD40 Antibody (C-term) (Ascites)Brand |
Leading Biology | Catalog Number |
AMM02430G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CD40 Antibody (C-term) (Ascites).
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Molecular Weight |
30619 Da
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Cellular Localization |
Antigen Cellular Localization:
Isoform I: Cell membrane; Single-pass type I membrane protein
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Host |
Mouse
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Species Reactivity |
Human
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Immunogen |
247-276 aa
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Target |
This CD40 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 247-276 amino acids from the C-terminal region of human CD40.
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Clone |
647CT13.2.4
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Isotype |
IgG1
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Symbol |
TNFRSF5
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GeneID |
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UniProt ID |
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Function |
Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.
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Summary |
The protein encoded by this gene is a member of theTNF-receptor superfamily. This receptor has been found to beessential in mediating a broad variety of immune and inflammatoryresponses including T cell-dependent immunoglobulin classswitching, memory B cell development, and germinal centerformation. AT-hook transcription factor AKNA is reported tocoordinately regulate the expression of this receptor and itsligand, which may be important for homotypic cell interactions.Adaptor protein TNFR2 interacts with this receptor and serves as amediator of the signal transduction. The interaction of thisreceptor and its ligand is found to be necessary foramyloid-beta-induced microglial activation, and thus is thought tobe an early event in Alzheimer disease pathogenesis. Twoalternatively spliced transcript variants of this gene encodingdistinct isoforms have been reported.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:100~1600
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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