> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > HGF AntibodyBrand |
Leading Biology | Catalog Number |
AMM02413G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality HGF Antibody.
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Molecular Weight |
83134 Da
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Host |
Mouse
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Species Reactivity |
Human
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Immunogen |
521-554 aa
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Target |
This HGF antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 521-554 amino acids from human HGF.
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Clone |
489CT6.12.6
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Isotype |
IgG1
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Symbol |
HPTA
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GeneID |
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UniProt ID |
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Function |
Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.
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Summary |
Hepatocyte growth factor regulates cell growth, cellmotility, and morphogenesis by activating a tyrosine kinasesignaling cascade after binding to the proto-oncogenic c-Metreceptor. Hepatocyte growth factor is secreted by mesenchymal cellsand acts as a multi-functional cytokine on cells of mainlyepithelial origin. Its ability to stimulate mitogenesis, cellmotility, and matrix invasion gives it a central role inangiogenesis, tumorogenesis, and tissue regeneration. It issecreted as a single inactive polypeptide and is cleaved by serineproteases into a 69-kDa alpha-chain and 34-kDa beta-chain. Adisulfide bond between the alpha and beta chains produces theactive, heterodimeric molecule. The protein belongs to theplasminogen subfamily of S1 peptidases but has no detectableprotease activity. Alternative splicing of this gene producesmultiple transcript variants encoding different isoforms. [providedby RefSeq].
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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