>
Antigen, Antibodies, ELISA, Western Blot >
Primary Antibody >
Monoclonal Antibodies >
FOXP3 (Forkhead Box Protein P3) / Scurfin Antibody - With BSA and AzideBrand |
Leading Biology | Catalog Number |
AMM00111G |
Product Type |
Monoclonal Antibodies | Field of Research |
|
Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality FOXP3 (Forkhead Box Protein P3) / Scurfin Antibody - With BSA and Azide.
|
||
Molecular Weight |
47-55kDa
|
||
Cellular Localization |
Antigen Cellular Localization:
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00089}
|
||
Host |
Mouse
|
||
Species Reactivity |
Human, Mouse, Monkey
|
||
Target |
Full-length human FOXP3 protein
|
||
Clone |
FXP3/197
|
||
Isotype |
IgG1, kappa
|
||
Symbol |
IPEX
|
||
GeneID |
|||
UniProt ID |
|||
Function |
Probable transcription factor. Plays a critical role in the control of immune response.
|
||
Summary |
Recognizes a protein of 47-55kDa, which is identified as FOXP3. Its precise epitope is not known, but it has been mapped to the N-terminal portion of the protein. The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung, with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. Mutations in FOXP3 gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T cell activation.
|
||
Form |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
||
Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
|
||
Applications |
IHC, IF, FC, IP, E
|
||
Images |
|
||
Specification |
|||
Quantity |
|
Select | Brand | Catalog No. | Product Name | Pack Size | Type | Field of Research | Specification | Quantity | Price(USD) | |
1 | Leading Biology | AMM07977G | SPRY1 / Sprouty 1 Antibody (clone 3H4) | 50 μg | Monoclonal Antibodies |
|
$545.00 | Add Ask | ||
2 | Leading Biology | AMM00137G | CD79a (B-Cell Marker) Antibody - With BSA and Azide | 50 ug | Monoclonal Antibodies |
|
$395.00 | Add Ask | ||
3 | Leading Biology | APG02467G | CCK4 / PTK7 Antibody (clone 4F9) | 50 μl | Monoclonal Antibodies |
|
$495.00 | Add Ask | ||
4 | Leading Biology | AMM05365G | DC-SIGN Antibody [5D7] | 0.1 mg | Monoclonal Antibodies |
|
$695.00 | Add Ask | ||
5 | Leading Biology | AMM01402G | Vimentin (Mesenchymal Cell Marker) Antibody - With BSA and Azide | 50 ug | Monoclonal Antibodies |
|
$395.00 | Add Ask | ||
6 | Leading Biology | APR08280G | LTA4H / LTA4 Antibody (clone 9G8) | 50 μl | Monoclonal Antibodies |
|
$495.00 | Add Ask |
Complete this form and click send to ask us a question, request a quote or simply say hello.
You have 0 item in your cart
You have 0 item in your inquiry list