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Anti-Human SELP Therapeutic Antibody (Crizanlizumab)Brand |
Leading Biology | Catalog Number |
AMH0001R |
Product Type |
Therapeutic Antibodies | Field of Research |
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Product Overview |
Recombinant monoclonal antibody to SELP. Crizanlizumab is a human monoclonal antibody that can be potentially used in the treatment of Sickle Cell Disease (SCD).
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Host |
CHO
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Species Reactivity |
Human
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Immunogen |
The details of the immunogen for this antibody are not available.
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Specificity |
Human SELP
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Conjugation |
Unconjugated
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Isotype |
IgG2, κ
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Purification |
Affinity purified
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GeneID |
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UniProt ID |
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Disease |
Sickle Cell Disease (SCD) |
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Purity |
> 95% as determined by SDS-PAGE |
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Storage & Stability |
Store at –20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile distilled water or diluent supplied, the antibody is stable for at least two weeks at 2-4 °C.
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Applications |
Used for immunoassay techniques such as: Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Immunofluorescence; Immunoprecipitation; Flow Cytometry; Functional Studies.
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Product Description |
This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calciumdependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented.
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Synonyms |
Selectin P; CD62
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Images |
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Specification |
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Quantity |
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