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DiMethyl-UHRF1-K385 pAb

Catalog # Availability Size / Price Inquiry
AMR00696N-1 50ul / $395
AMR00696N-2 100ul / $495
AMR00696N-3 200ul / $595

DiMethyl-UHRF1-K385 pAb

Brand

Leading Biology

Catalog Number

AMR00696N

Product Type

Methylated Antibodies

Field of Research

Cell Biology & Developmental Biology>Apoptosis

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality DiMethyl-UHRF1-K385 pAb.

Molecular Weight

Calculated MW: 89kDa/91kDa Observed MW: _

Species Reactivity

Rabbit

Immunogen

A synthetic monomethylated peptide around K385 of human UHRF1 (NP_001041666.1).

Cross Reactivity

Human,Mouse

Isotype

IgG

GeneID

UniProt ID

Purity

Affinity purification

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Storage Buffer

Buffer: PBS with 50% glycerol, pH7.3.

Applications

IHC,IF

Dilution

IHC 1:50 - 1:200 IF 1:50 - 1:200

Product Description

This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.

Synonyms

UHRF1; ICBP90; Np95; RNF106; TDRD22; hNP95; hUHRF1; huNp95; E3 ubiquitin-protein ligase UHRF1

Images

Immunofluorescence analysis of U2OS cells using DiMethyl-UHRF1-K385 antibody.

Specification

Quantity

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