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Methylated Antibodies >
DiMethyl-UHRF1-K385 pAbBrand |
Leading Biology | Catalog Number |
AMR00696N |
Product Type |
Methylated Antibodies | Field of Research |
Cell Biology & Developmental Biology>Apoptosis |
Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality DiMethyl-UHRF1-K385 pAb.
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Molecular Weight |
Calculated MW:
89kDa/91kDa
Observed MW:
_
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Species Reactivity |
Rabbit
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Immunogen |
A synthetic monomethylated peptide around K385 of human UHRF1 (NP_001041666.1).
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Cross Reactivity |
Human,Mouse
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Isotype |
IgG
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GeneID |
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UniProt ID |
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Purity |
Affinity purification |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Storage Buffer |
Buffer: PBS with 50% glycerol, pH7.3.
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Applications |
IHC,IF
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Dilution |
IHC 1:50 - 1:200
IF 1:50 - 1:200
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Product Description |
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.
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Synonyms |
UHRF1; ICBP90; Np95; RNF106; TDRD22; hNP95; hUHRF1; huNp95; E3 ubiquitin-protein ligase UHRF1
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Images |
Immunofluorescence analysis of U2OS cells using DiMethyl-UHRF1-K385 antibody. |
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Specification |
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Quantity |
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Select | Brand | Catalog No. | Product Name | Pack Size | Type | Field of Research | Specification | Quantity | Price(USD) | |
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5 | Leading Biology | AMR00724N | TriMethyl-Histone H3-K79 pAb | 100ul | Methylated Antibodies | Epigenetics & Nuclear Signaling>Epigenetic Modifications |
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6 | Leading Biology | AMR00722N | MonoMethyl-Histone H3-K79 pAb | 100ul | Methylated Antibodies | Epigenetics & Nuclear Signaling>Epigenetic Modifications |
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$495.00 | Add Ask |
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