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p38 MAPK Monoclonal Antibody

Catalog # Availability Size / Price Inquiry
AMR00687N-1 50ul / $395
AMR00687N-2 100ul / $495
AMR00687N-3 200ul / $595

p38 MAPK Monoclonal Antibody

Brand

Leading Biology

Catalog Number

AMR00687N

Product Type

Monoclonal Antibodies

Field of Research

Cardiovascular>Angiogenesis

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality p38 MAPK Monoclonal Antibody.

Molecular Weight

Calculated MW: 29kDa/34kDa/35kDa/41kDa Observed MW: 41kDa

Species Reactivity

Rabbit

Immunogen

A synthetic synthetic peptide of human p38 MAPK (NP_620581.1).

Cross Reactivity

Human,Mouse,Rat

Isotype

IgG

GeneID

UniProt ID

Purity

Affinity purification

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Storage Buffer

Buffer: PBS with 50% glycerol, pH7.3.

Applications

WB,IHC

Dilution

WB 1:500 - 1:2000IHC 1:50 - 1:200

Product Description

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Synonyms

MAPK14; CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; PRKM14; PRKM15; RK; SAPK2A; p38; p38ALPHA; mitogen-activated protein kinase 14

Images

Western blot analysis of extracts of various cell lines, using p38 MAPK antibody.

Specification

Quantity

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