> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > LRP-5/6 Antibody (Clone 1A12)Brand |
Leading Biology | Catalog Number |
APR08268G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality LRP-5/6 antibody (Clone 1A12).
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Molecular Weight |
179145 Da
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Cellular Localization |
Antigen Cellular Localization:
Membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Note=Chaperoned to the plasma membrane by MESD.
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Host |
Mouse
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Species Reactivity |
Human, Mouse
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Target |
LRP-5/6
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Isotype |
Mouse IgG2bk
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Symbol |
LR3, LRP7
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GeneID |
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UniProt ID |
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Function |
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.
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Summary |
LDL-related proteins, LRP-5 and LRP-6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP-6 was shown to bind to Wnt-1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP-6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP-5 to Axin, leading Axin degradation and β-catenin stabilization.
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Form |
100 μg (1 mg/ml) purified antibody in 10 mM Tris-glycine (pH 7.0), 0.15 M NaCl, 25% glycerol, 0.5% BSA, and 0.01% sodium azide. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB
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Synonyms |
LRP-5, LRP-6, LDL-related protein, LDL receptor, Axin, beta-catenin
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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