> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > APAF1 / APAF-1 Antibody (aa1-464, clone 2E12, Low Endotoxin)Brand |
Leading Biology | Catalog Number |
APG01902G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality APAF1 / APAF-1 antibody (aa1-464, clone 2E12, Low Endotoxin).
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Molecular Weight |
141840 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm.
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Host |
Rat
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Species Reactivity |
Human
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Target |
Recognizes the CARD domain of human Apaf-1. Does not cross-react with mouse or rat Apaf-1.
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Clone |
2E12
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Isotype |
IgG2a,k
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Symbol |
KIAA0413
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GeneID |
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UniProt ID |
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Function |
Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
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Summary |
Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
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Form |
Liquid |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC-P, ICC, E, IP
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Dilution |
IHC-P (10 μg/ml), IP (1:1000 - 1:2000), IP (1:1000 - 1:2000), WB (1:1000 - 1:2000),
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Synonyms |
APAF1, APAF-1, CED4, KIAA0413
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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