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Neurofilament H (NF-H) Antibody

Catalog # Availability Size / Price Inquiry
AMM06633G 100 μl / $495

Neurofilament H (NF-H) Antibody

Brand

Leading Biology

Catalog Number

AMM06633G

Product Type

Monoclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Neurofilament H (NF-H) antibody.

Molecular Weight

200 KDa

Host

Mouse

Species Reactivity

Rat

Target

Purified bovine NF-H.

Clone

NAP4

Isotype

IgG1

GeneID

UniProt ID

Summary

Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H (1). NF-H is the neurofilament high or heavy molecular weight polypeptide and runs on SDS-PAGE gels at 200-220 kDa, with some variability across species boundaries. Antibodies to NF-H are useful for identifying neuronal cells and their processes in tissue sections and in tissue culture. NF-H antibodies can also be useful to visualize neurofilament accumulations seen in many neurological diseases, such as Amyotrophic Lateral Sclerosis (Lou Gehrig's disease) (2) and Alzheimer's disease (3).

Form

Unpurified mouse ascites fluid.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

IF, WB

Dilution

WB~~ 1:5000 IF~~ 1:500

Synonyms

Neurofilament heavy polypeptide, NF-H, 200 kDa neurofilament protein, Neurofilament triplet H protein, NEFH, KIAA0845, NFH

Images

Western blot of rat cortex lysate showing specific immunolabeling of the ~ 200k NF-H protein.

Immunostaining of human cerebellar cortex showing labeling of NF-H (brown) in basket cell axons surrounding the large Purkinje neurons.

Specification

Quantity

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