Location: Home > Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > PIN1 Antibody

PIN1 Antibody

APR12868G Product Datasheet Protocol

Catalog #	Availability	Size / Price	Inquiry
APR12868G		100 μl / $495

Bulk Orders Inquiry

3 Images

Contact Information

Leading Biology Inc.

tel:1-661-524(LBI)-0262
Info@leadingbiology.com

Show All Distributors

PIN1 Antibody

Brand	Leading Biology	Catalog Number	APR12868G
Product Type	Monoclonal Antibodies	Field of Research
Product Overview	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PIN1 antibody.
Molecular Weight	18243 Da
Cellular Localization	Antigen Cellular Localization: Nucleus. Nucleus speckle. Cytoplasm. Note=Colocalizes with NEK6 in the nucleus. Mainly localized in the nucleus but phosphorylation at Ser-71 by DAPK1 results in inhibition of its nuclear localization
Host	Mouse
Species Reactivity	Human, Mouse, Rat, African Green Monkey
Target	Purified His-tagged PIN1 protein was used to produced this monoclonal antibody.
Clone	855CT1.7.5
Isotype	IgG1
GeneID	5300
UniProt ID	Q13526
Function	Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner.
Summary	Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.
Form	Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Storage & Stability	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Applications	IHC-P, FC, WB, E
Dilution	IHC-P~~1:25 FC~~1:25 WB~~1:1000
Synonyms	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, Peptidyl-prolyl cis-trans isomerase Pin1, PPIase Pin1, Rotamase Pin1, PIN1
Images	AM2212B staining PIN1 in human brain tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody (1/25) for 1 hours at 37°C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody. AM2212B staining PIN1 in human testis tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody (1/25) for 1 hours at 37°C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody. AW5186 staining PIN1 in human liver tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody (1/25) for 1 hours at 37°C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody.
Specification	Product Datasheet Protocol
Quantity

Add to cart Inquiry

Previous Product: LCK Antibody(Ascites) Next Product: FGF23 (Fibroblast Growth Factor 23) Anti...

Best Sellers

Related Products

Select	Brand	Catalog No.	Product Name	Pack Size	Type	Field of Research	Specification	Quantity	Price(USD)
1	Leading Biology	APG02467G	CCK4 / PTK7 Antibody (clone 4F9)	50 μl	Monoclonal Antibodies				$495.00	Add Ask
2	Leading Biology	AMM04683G	GALT Antibody (clone 4C11)	50 μg	Monoclonal Antibodies				$545.00	Add Ask
3	Leading Biology	AMM01402G	Vimentin (Mesenchymal Cell Marker) Antibody - With BSA and Azide	50 ug	Monoclonal Antibodies				$395.00	Add Ask
4	Leading Biology	APR08280G	LTA4H / LTA4 Antibody (clone 9G8)	50 μl	Monoclonal Antibodies				$495.00	Add Ask
5	Leading Biology	AMM00172G	CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - With BSA and Azide	50 ug	Monoclonal Antibodies				$395.00	Add Ask
6	Leading Biology	AMM05750G	CEBPA Antibody	100 μl	Monoclonal Antibodies				$545.00	Add Ask