> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > TLR3 AntibodyBrand |
Leading Biology | Catalog Number |
APR11216G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TLR3 antibody.
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Molecular Weight |
103829 Da
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Cellular Localization |
Antigen Cellular Localization:
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane
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Host |
Mouse
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Species Reactivity |
Human, Mouse
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Target |
This TLR3 monoclonal antibody is generated from mouse immunized with TLR3 recombinant protein.
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Clone |
303CT19.9.2
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Isotype |
IgM,k
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GeneID |
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UniProt ID |
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Function |
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.
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Summary |
The protein encoded by this gene is a member of theToll-like receptor (TLR) family which plays a fundamental role inpathogen recognition and activation of innate immunity. TLRs arehighly conserved from Drosophila to humans and share structural andfunctional similarities. They recognize pathogen-associatedmolecular patterns (PAMPs) that are expressed on infectious agents,and mediate the production of cytokines necessary for thedevelopment of effective immunity. The various TLRs exhibitdifferent patterns of expression. This receptor is most abundantlyexpressed in placenta and pancreas, and is restricted to thedendritic subpopulation of the leukocytes. It recognizes dsRNAassociated with viral infection, and induces the activation ofNF-kappaB and the production of type I interferons. It may thusplay a role in host defense against viruses. Use of alternativepolyadenylation sites to generate different length transcripts hasbeen noted for this gene.
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Form |
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:100
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Synonyms |
Toll-like receptor 3, CD283, TLR3
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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