> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > ACHE Antibody (C-term) (Ascites)Brand |
Leading Biology | Catalog Number |
AMM05536G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality ACHE antibody (C-term) (Ascites).
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Molecular Weight |
67796 Da
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Cellular Localization |
Antigen Cellular Localization:
Cell junction, synapse Secreted. Cell membrane; Peripheral membrane protein Isoform H: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side
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Host |
Mouse
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Species Reactivity |
Human, Hamster
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Immunogen |
582-610 aa
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Target |
This ACHE antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 582-610 amino acids from the C-terminal region of human ACHE.
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Clone |
684CT8.3.4
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Isotype |
IgG1
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GeneID |
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UniProt ID |
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Function |
Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.
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Summary |
Acetylcholinesterase hydrolyzes the neurotransmitter,acetylcholine at neuromuscular junctions and brain cholinergicsynapses, and thus terminates signal transmission. It is also foundon the red blood cell membranes, where it constitutes the Yt bloodgroup antigen. Acetylcholinesterase exists in multiple molecularforms which possess similar catalytic properties, but differ intheir oligomeric assembly and mode of cell attachment to the cellsurface. It is encoded by the single ACHE gene, and the structuraldiversity in the gene products arises from alternative mRNAsplicing, and post-translational associations of catalytic andstructural subunits. The major form of acetylcholinesterase foundin brain, muscle and other tissues is the hydrophilic species,which forms disulfide-linked oligomers with collagenous, orlipid-containing structural subunits. The other, alternativelyspliced form, expressed primarily in the erythroid tissues, differsat the C-terminal end, and contains a cleavable hydrophobic peptidewith a GPI-anchor site. It associates with the membranes throughthe phosphoinositide (PI) moieties added post-translationally.
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Form |
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:200~3200
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Synonyms |
Acetylcholinesterase, AChE, ACHE
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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