> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > DISC1 AntibodyBrand |
Leading Biology | Catalog Number |
APR11722G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality DISC1 antibody.
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Molecular Weight |
93611 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Colocalizes with NDEL1 in the perinuclear region and the centrosome (By similarity) Localizes to punctate cytoplasmic foci which overlap in part with mitochondria. Colocalizes with PCNT at the centrosome
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Host |
Mouse
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Species Reactivity |
Human
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Immunogen |
701-728 aa
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Target |
This DISC1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 701-728 amino acids from human DISC1.
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Clone |
584CT4.2.1
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Isotype |
IgM
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Symbol |
KIAA0457
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GeneID |
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UniProt ID |
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Function |
Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.
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Summary |
This gene encodes a protein with multiple coiled coilmotifs which is located in the nucleus, cytoplasm and mitochondria.The protein is involved in neurite outgrowth and corticaldevelopment through its interaction with other proteins. This geneis disrupted in a t(1;11)(q42.1;q14.3) translocation whichsegregates with schizophrenia and related psychiatric disorders ina large Scottish family. Alternate transcriptional splice variants,encoding different isoforms, have been characterized. [provided byRefSeq].
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Form |
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:100~250
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Synonyms |
Disrupted in schizophrenia 1 protein, DISC1, KIAA0457
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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