> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > FMR1 Antibody (Ascites)Brand |
Leading Biology | Catalog Number |
AMM05882G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality FMR1 antibody (Ascites).
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Molecular Weight |
71174 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm. Nucleus, nucleolus.
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Host |
Mouse
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Species Reactivity |
Human
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Immunogen |
20-48 aa
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Target |
This FMR1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 20-48 amino acids from human FMR1.
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Clone |
508CT17.2.2
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Isotype |
IgM
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GeneID |
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UniProt ID |
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Function |
Translation repressor. Component of the CYFIP1-EIF4E- FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity). RNA- binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C).
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Summary |
The protein encoded by this gene binds RNA and isassociated with polysomes. The encoded protein may be involved inmRNA trafficking from the nucleus to the cytoplasm. A trinucleotiderepeat (CGG) in the 5' UTR is normally found at 6-53 copies, but anexpansion to 55-230 repeats is the cause of fragile X syndrome.Expansion of the trinucleotide repeat may also cause one form ofpremature ovarian failure (POF1). Multiple alternatively splicedtranscript variants that encode different protein isoforms andwhich are located in different cellular locations have beendescribed for this gene.
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Form |
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:500~8000
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Synonyms |
Fragile X mental retardation protein 1, FMRP, Protein FMR-1, FMR1
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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