> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > MX1 AntibodyBrand |
Leading Biology | Catalog Number |
APR10939G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality MX1 antibody.
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Molecular Weight |
75520 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, perinuclear region. Note=Binds preferentially to negatively charged phospholipids. Colocalizes with CCHFV protein N in the perinuclear region
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Host |
Mouse
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Species Reactivity |
Human
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Immunogen |
617-646 aa
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Target |
This MX1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 617-646 amino acids from human MX1.
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Clone |
474CT4.1.5
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Isotype |
IgG2b
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GeneID |
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UniProt ID |
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Function |
Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.
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Summary |
In mouse, the interferon-inducible Mx protein isresponsible for a specific antiviral state against influenza virusinfection. The protein encoded by this gene is similar to the mouseprotein as determined by its antigenic relatedness, inductionconditions, physicochemical properties, and amino acid analysis.This cytoplasmic protein is a member of both the dynamin family andthe family of large GTPases. Two transcript variants encoding thesame protein have been found for this gene.
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Form |
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:100~500
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Synonyms |
Interferon-induced GTP-binding protein Mx1, Interferon-induced protein p78, IFI-78K, Interferon-regulated resistance GTP-binding protein MxA, Myxoma resistance protein 1, Myxovirus resistance protein 1, Interferon-induced GTP-binding protein Mx1, N-terminally processed, MX1
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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