> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > DDR2 Antibody(Ascites)Brand |
Leading Biology | Catalog Number |
APR11715G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality DDR2 antibody(Ascites).
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Molecular Weight |
96736 Da
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Cellular Localization |
Antigen Cellular Localization:
Cell membrane; Single- pass type I membrane protein
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Host |
Mouse
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Species Reactivity |
Human
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Immunogen |
290-320 aa
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Target |
This DDR2 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 290-320 amino acids from human DDR2.
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Clone |
484CT5.5.4
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Isotype |
IgG1
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Symbol |
NTRKR3, TKT, TYRO10
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GeneID |
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UniProt ID |
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Function |
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.
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Summary |
Receptor tyrosine kinases (RTKs) play a key role in thecommunication of cells with their microenvironment. These moleculesare involved in the regulation of cell growth, differentiation, andmetabolism. In several cases the biochemical mechanism by whichRTKs transduce signals across the membrane has been shown to beligand induced receptor oligomerization and subsequentintracellular phosphorylation. This autophosphorylation leads tophosphorylation of cytosolic targets as well as association withother molecules, which are involved in pleiotropic effects ofsignal transduction. RTKs have a tripartite structure withextracellular, transmembrane, and cytoplasmic regions. This geneencodes a member of a novel subclass of RTKs and contains adistinct extracellular region encompassing a factor VIII-likedomain. Alternative splicing in the 5' UTR results in multipletranscript variants encoding the same protein. [provided byRefSeq].
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Form |
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:100~1600
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Synonyms |
Discoidin domain-containing receptor 2, Discoidin domain receptor 2, CD167 antigen-like family member B, Discoidin domain-containing receptor tyrosine kinase 2, Neurotrophic tyrosine kinase, receptor-related 3, Receptor protein-tyrosine kinase TKT, Tyrosine-protein kinase TYRO10, CD167b, DDR2, NTRKR3, TKT, TYRO10
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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