> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > FGA Antibody (N-term) (Ascites)Brand |
Leading Biology | Catalog Number |
AMM04536G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality FGA antibody (N-term) (Ascites).
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Molecular Weight |
94973 Da
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Cellular Localization |
Antigen Cellular Localization:
Secreted.
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Host |
Mouse
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Species Reactivity |
Human, Mouse
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Immunogen |
116-144 aa
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Target |
This FGA antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 116-144 amino acids from the N-terminal region of human FGA.
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Clone |
471CT12.1.2
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Isotype |
IgM
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GeneID |
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UniProt ID |
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Function |
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3- dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.
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Summary |
The protein encoded by this gene is the alpha component offibrinogen, a blood-borne glycoprotein comprised of three pairs ofnonidentical polypeptide chains. Following vascular injury,fibrinogen is cleaved by thrombin to form fibrin which is the mostabundant component of blood clots. In addition, various cleavageproducts of fibrinogen and fibrin regulate cell adhesion andspreading, display vasoconstrictor and chemotactic activities, andare mitogens for several cell types. Mutations in this gene lead toseveral disorders, including dysfibrinogenemia, hypofibrinogenemia,afibrinogenemia and renal amyloidosis. Alternative splicing resultsin two isoforms which vary in the carboxy-terminus. [provided byRefSeq].
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Form |
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:500~2000
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Synonyms |
Fibrinogen alpha chain, Fibrinopeptide A, Fibrinogen alpha chain, FGA
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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